Intraosseous Pressure as a Measure of Hemodynamic Changes in Bone Marrow

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Abstract
The range of the variation of individual intraosseous pressure was very wide, and no particular correlation between systemic blood pressure and intraosseous pressure was noted. Intraosseous pressure was extremely sensitive to the volume of inflow and/or outflow of the bone. The intraosseous pressure in the diaphysis was significantly higher than that in the epi-physis. The pressure applied to the diaphyseal marrow of the mature bone was transmitted easily throughout the diaphyseal marrow, but its transmission to the epiphyseal marrow was markedly reduced. The result suggests the existence of a hemodynamic barrier between the epiphysis and the diaphysis in mature bone. Pulsatile and respiratory waves were always observed in intraosseous pressure. In a few cases, slow periodic undulations in the level of intraosseous pressure were observed in association with or without similar undulations in systemic blood pressure. The effect of autonomimetic drugs on intraosseous pressure varied with their effects both on systemic blood pressure and on the local mechanism, whose responses to the nerve stimulation and the drugs were considered to be similar to that of the blood vessels innervating another part of the body. Vasomotor innervation of the femur and the tibiofibula could be deduced from comparison between the changes in systemic blood pressure and those in intraosseous pressure brought about by a nerve stimulation. A new method for estimating mean blood flow through a bone was devised. A close relation between the rate of flow and intraosseous pressure was observed in the perfused hind leg of a dog.

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