Arousal and inhibition of human NK cells
- 1 February 1997
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 155 (1) , 145-154
- https://doi.org/10.1111/j.1600-065x.1997.tb00947.x
Abstract
NK cells express receptors for polymorphic MHC class I molecules that inhibit killing of potential target cells bearing appropriate class I allotypes. Here we review the membrane receptors on human NK cells that are known to initiate cell-mediated cytotoxicity and demonstrate regulation of these responses by the killer cell inhibitory (KIR) receptors.Keywords
This publication has 98 references indexed in Scilit:
- CD28/B7 SYSTEM OF T CELL COSTIMULATIONAnnual Review of Immunology, 1996
- Inhibitory MHC class I receptors on NK and T cells: a standard nomenclatureImmunology Today, 1996
- Specificity of HLA class I antigen recognition by human NK clones: evidence for clonal heterogeneity, protection by self and non-self alleles, and influence of the target cell type.The Journal of Experimental Medicine, 1993
- Association of a 70‐kDa tyrosine phosphoprotein with the CD16:ζ:γ complex expressed in human natural killer cellsEuropean Journal of Immunology, 1993
- The role of natural killer cells in innate resistance to infectionCurrent Opinion in Immunology, 1993
- RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangementCell, 1992
- Restoration of a tumorigenic phenotype by beta 2-microglobulin transfection to EL-4 mutant cells.The Journal of Experimental Medicine, 1992
- CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes.The Journal of Experimental Medicine, 1992
- ‘Nonspecific’ MHC-unrestricted killer cells and their receptorsImmunology Today, 1987
- Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism.The Journal of Experimental Medicine, 1985