Fortimicins A and B, new aminoglycoside antibiotics. III. Structural identification.
- 1 January 1977
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 30 (7) , 552-563
- https://doi.org/10.7164/antibiotics.30.552
Abstract
The structures of fortimicins A and B were determined by PMR, CMR [carbon magnetic resonance], mass spectra and CD [circular dichroism] combined with chemical degradations. Both antibiotics are pseudodisaccharides and incorporate a novel aminocyclitol, fortamine. In contrast to the diaminocyclitol moieties of known aminglycosides, fortamine is a 1,4-diamine, contains N- and O-methyl groups and possesses chiro stereochemistry. Both antibiotics are glycosides of 6-epi-purpurosamine B, but fortimicin A differs from fortimicin B by being a glycyl amide.This publication has 4 references indexed in Scilit:
- A new aminoglycoside antibiotic complex - The seldomycins. IV. The structure of seldomycin factor 5.The Journal of Antibiotics, 1977
- A new aminoglycoside antibiotic complex - The seldomycins. III. The structures of seldomycin factors 1 and 2.The Journal of Antibiotics, 1977
- Fortimicins A and B, new aminoglycoside antibiotics. II. Isolation, physico-chemical and chromatographic properties.The Journal of Antibiotics, 1977
- Fortimicins A and B, new aminoglycoside antibiotics. I. Producing organism, fermentation a biological properties of fortimicins.The Journal of Antibiotics, 1977