ACQUIRED APLASTIC-ANEMIA IN ADULTS .4. HISTOLOGICAL AND CFU STUDIES IN TRANSPLANTED AND NON-TRANSPLANTED PATIENTS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 19  (2) , 159-171
Abstract
A follow up study of 10 patients suffering from acquired aplastic anemia, comprising methacrylate-embedded bone marrow biopsies and CFU [colony forming units] cultures, is presented. The hematopoietic recovery patterns and changes in the inflammatory infiltration after permanent engraftment could be distinguished from those in non-transplanted patients. After anti-thymocyte globulin treatment followed by allogeneic bone marrow infusion, the recovery pattern resembled that in non-transplanted patients. The persistently low colony-forming capacity in some patients could be explained by the existence of lymphoid inhibitory cells, which suggests an immunologic auto-destructive mechanism.