Anatomic Localization of the Response to Ultraviolet Radiation in Human Skin

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Abstract
In an attempt to elucidate the site of injury from ultraviolet radiation (UVR) in human skin, histologic evaluation was performed after irradiation with the various ranges in the UV spectrum. Response to UVA (320–400 nm) irradiation produced changes varying from predominantly dermal (normal) to showing significant epidermal participation (abnormal). UVB (290–320 nm) irradiation produced both dermal and epidermal alterations, developing a moderate perivascular response in normal individuals and increasing to an intense vasculitis with marked epidermal changes in subjects with light associated diseases. UVC (200–290 nm) irradiation induced intense epidermal reactions and only a mild perivascular response. The common denominator in all instances is the apparent vascular injury.

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