Triiodothyronine: The 3′-Iodine Is Proximal to the α-Ring in Crystal Structure Conformation
- 18 February 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 175 (4023) , 764-766
- https://doi.org/10.1126/science.175.4023.764
Abstract
The crystal and molecular structure of the thyroid hormone L-triiodothyronine has been determined by x-ray diffraction. The two phenyl rings are almost perpendicular to each other, the acute angle between their normals being 82 degrees. The 3′-iodine is situated proximal to the α-ring, rather than distal as inferred from chemical studies. Theoretical calculations indicate this proximal conformation to be energetically favored over the distal one.Keywords
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