Regional Heparinization for Hemodialysis

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Abstract
SINCE the clinical application of extracorporeal hemodialysis requires the addition of an anticoagulant to the blood, hemorrhagic complications may occur in the patient.In the usual procedure, 6000 to 9000 U.S.P. units of heparin sodium (about 60 to 90 mg.) are added to the blood used to prime the artificial kidney. When the dialyzer is connected to the patient, there is a systemic effect. Anticoagulant activity is monitored by serial determinations of clotting times by the Lee and White method. When the clotting time falls below sixty minutes, 1000 to 2000 U.S.P. units (about 10 to 20 mg.) . . .

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