SOME IMPLICATIONS OF ADDITION OF TWEEN 80 TO DILUTIONS OF PPD TUBERCULIN WITH RESPECT TO STUDY OF SPECIFIC AND NONSPECIFIC TUBERCULIN SENSITIVITY - A PRELIMINARY REPORT

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Abstract
Duplicate tests of human PPD in a diluent containing 0.05% of Tween 80 and 2.5 times as much of the same tuberculin diluted in phosphate buffer not containing Tween were given to: a general population in a district where clinical tuberculosis is unknown, a general population in a district where clinical tuberculosis is common, and persons with bacteriologically proved cases of tuberculosis. The patients with proved tuberculosis and persons who had reactions of the same size as are normally found in clinical tuberculosis had reactions of approximately the same size to both tests. Persons who had reactions of a size such as are commonly found in districts where clinical tuberculosis is unknown, however, had much smaller reactions to the tuberculin containing Tween than to 2.5 times as much of the same tuberculin not containing Tween.

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