Negative Regulation of the Osteoblast Function in Multiple Myeloma through the Repressor Gene E4BP4 Activated by Malignant Plasma Cells
Open Access
- 30 September 2008
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 14 (19) , 6081-6091
- https://doi.org/10.1158/1078-0432.ccr-08-0219
Abstract
Purpose: To explore the pathogenetic mechanisms that suppress the osteoblast function in multiple myeloma because osteogenesis results in defective new bone formation and repair.Keywords
This publication has 48 references indexed in Scilit:
- Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathwayJournal of Clinical Investigation, 2007
- Calcium-dependent upregulation of E4BP4 expression correlates with glucocorticoid-evoked apoptosis of human leukemic CEM cellsBiochemical and Biophysical Research Communications, 2006
- In-vitro functional phenotypes of plasma cell lines from patients with multiple myelomaLeukemia & Lymphoma, 2006
- Anti-α4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysisBlood, 2004
- The CES-2-related transcription factor E4BP4 is an intrinsic regulator of motoneuron growth and survivalDevelopment, 2004
- E4BP4/NFIL3, a PAR‐related bZIP factor with many rolesBioEssays, 2002
- GATA Factors Are Essential for Transcription of the Survival Gene E4bp4 and the Viability Response of Interleukin-3 in Ba/F3 Hematopoietic CellsJournal of Biological Chemistry, 2002
- Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodMethods, 2001
- Regulation of Parathyroid Hormone-Related Protein Expression in MCF-7 Breast Carcinoma Cells by Estrogen and AntiestrogensBiochemical and Biophysical Research Communications, 1998
- Inducibility of E4BP4 Suggests a Novel Mechanism of Negative Gene Regulation by GlucocorticoidsBiochemical and Biophysical Research Communications, 1997