Cells of the synovium in rheumatoid arthritis. T lymphocytes
Open Access
- 1 January 2007
- journal article
- review article
- Published by Springer Nature in Arthritis Research & Therapy
- Vol. 9 (1) , 202
- https://doi.org/10.1186/ar2107
Abstract
Recent findings have substantiated the importance of T lymphocytes to the pathogenesis of rheumatoid arthritis (RA). Here, we review emerging data regarding genetic predisposition, spontaneous animal models of arthritis, and cell-cell interactions that implicate T cells as driving synovial inflammation and joint destruction. Information regarding the proinflammatory role of interleukin-17-producing T cells and the functional state of regulatory T cells both in animal models and in patients with RA is also discussed. In light of the overwhelming evidence that disrupted T-cell homeostasis greatly contributes to joint pathology in RA, the therapeutic potential of targeting activators of pro-inflammatory T cells or their products is compelling.Keywords
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