Effect of ADP on PGE1Formation in Blood Platelets from Patients with Depression, Mania and Schizophrenia
- 1 December 1975
- journal article
- Published by Royal College of Psychiatrists in The British Journal of Psychiatry
- Vol. 127 (6) , 591-595
- https://doi.org/10.1192/bjp.127.6.591
Abstract
Summary: Adenosine diphosphate (ADP) stimulates the synthesis of prostaglandin E1(PGE1) in lysed platelets from normal subjects, patients with affective illness but not in platelets from cases of schizophrenia. The stimulation is concentration-dependent and follows a curve which is mildly sigmoid in the normal, markedly sigmoid in depression and hyperbolic in mania.Keywords
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