Effects of severe acute hypoxia on the distribution of cardiac electrolytes and water

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Abstract
Rats were exposed to 4.85% oxygen at ambient temperature for 5 to 7 h, conditions which proved lethal for about one-third of the population and left the survivors moribund. Despite the severity of the hypoxia, the myocardial electrolyte (Na, K, Ca, Mg, CI) and water contents and distributions remained unchanged, except for a slight increase in cellular potassium and probably also of sodium. It is proposed that the electrolyte and water derangements frequently observed after coronary occlusion, myocardial infarction, fibrillation, or other conditions of ischaemic hypoxia, are not the cause of cardiac arrest but instead occur as a consequence of haemostasis.

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