THE EFFECT OF HALOTHANE ON THE ISOLATED CAT HEART

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Abstract
The effect of The effect of halothane on the electrocardiogram recorded from the isolated perfused cat heart is described. A halothane tension of between 7 and 14 mm Hg produced bradycardia, atrioventricular dissociation, nodal rhythm and finally asystole. Conditions of low oxygen tension and high carbon dioxide tension produced ventricular extrasystoles in isolated hearts exposed to halothane. It is suggested that this provides corroborative evidence for the contention that the ventricular extrasystoles produced by halothane in cats can occur independently of sympatho-adrenal activity.