A simple method of preparing trimethylsilyl- and tert-butyldimethylsilyl-enol ethers of α-diazoacetoacetates and their use in the synthesis of a chiral precursor to thienamycin analogs
- 1 December 1984
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 62 (12) , 2936-2940
- https://doi.org/10.1139/v84-497
Abstract
A simple method of preparing trimethylsilyl- and tert-butyldimethylsilyl-enol ethers of various esters of .alpha.-diazoacetoacetic acid is described. Displacement reaction of 4-acetoxyacetidinone with tert-butyldimethylsilylenol ethers, followed by desilylation, afforded the key chiral precursor for the synthesis of thienamycin analogs [potential antibiotics].This publication has 0 references indexed in Scilit: