Evidence for a Possible Dopaminergic Control of Pituitary Alpha-MSH during Ontogenesis in Mice
- 1 January 1981
- journal article
- research article
- Published by S. Karger AG in Neuroendocrinology
- Vol. 33 (5) , 306-311
- https://doi.org/10.1159/000123250
Abstract
The .alpha.-MSH and ACTH contents of the neurointermediate lobe (NIL) of the mouse hypophysis during ontogenesis, and the ability of the gland, incubated in a perfusion system, to respond to dopamine (DA) and high K+ were determined. The NIL content of .alpha.-MSH exhibited a biphasic pattern of evolution, characterized by a dramatic increase appearing between postnatal days 3 and 5. NIL ACTH content followed a completely different pattern of evolution; both DA and high K+ reversibly inhibited MSH release from superfused NIL, the latter effect being more pronounced with the use of pituitaries from 7 day old than from 1 day old mice; the inhibitory influence of high K+ was impaired by haloperidol pretreatment. Functional DA receptors seem to be present on melanotrophs of the developing hypophysis in mice and the increase in .alpha.-MSH in IL cells observed shortly after birth may result from the onset of inhibitory influence exerted by dopaminergic innervation on hormonal secretion. This view does not preclude possible effects of other hypothalamic releasing and/or inhibiting factors.This publication has 12 references indexed in Scilit:
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