Inhibition of Skin Tumorigenesis in Strain B6AF1/J Female Mice With Maleic Anhydride2

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Abstract
Induction of skin tumors with 7,12-dimethylbenz[α]anthracene (DMBA) alone, or DMBA and croton oil, in strain B6AF1/J hybrid mice was inhibited when maleic anhydride (MA) was applied repeatedly to an area of skin exposed to carcinogen. Inhibition was noted when MA was administered prior to, but not after, treatment with DMBA, as reflected in a prolonged latent period and a decreased tumor yield. Similar results were obtained whether or not the mice were treated with croton oil in addition to DMBA. No inhibition occurred when treatments with MA and croton oil were alternated. Inhibition appeared to be directed against the “initiating” rather than the “promoting” stage of skin tumorigenesis.