Deciphering the pathway from the TCR to NF-κB
- 27 January 2006
- journal article
- review article
- Published by Springer Nature in Cell Death & Differentiation
- Vol. 13 (5) , 826-833
- https://doi.org/10.1038/sj.cdd.4401856
Abstract
A major regulator of lymphocyte survival and activation is the transcription factor nuclear factor-κB (NF-κB). Controlled activation of NF-κB is essential for the immune and inflammatory response as well as for cell proliferation and protection against apoptosis. The NEMO/IκB kinase (IKK) complex is the central integrator of most stimuli leading to NF-κB activation, but a detailed knowledge of the upstream events is available only for a limited number of stimuli. In particular, although most players have probably been identified, relatively little is known about the detailed molecular mechanisms involved in the cascade leading to NF-κB activation following engagement of the T-cell receptor by a foreign antigen. In this review, we discuss recent insights into this specific signal transduction cascade, and the way it is controlled both spatially and temporally.Keywords
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