Independent Developmental Programs for Two Estrogen-Regulated Genes
- 10 August 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 225 (4662) , 639-641
- https://doi.org/10.1126/science.6740331
Abstract
Measurement of hepatic apolipoprotein II and vitellogenin II messenger RNA during chicken embryogenesis showed that these genes acquire estrogen responsiveness at different stages of development. Sensitive solution hybridization assays with excess complementary DNA showed that apolipoprotein II transcripts were induced to 500 molecules per cell at day 9, whereas induction of vitellogenin II messenger RNA was not found until day 11. Thus, two estrogen regulated genes of common function and coordinately regulated in the adult may be on independent developmental programs.This publication has 15 references indexed in Scilit:
- Temporal order of chromatin structural changes associated with activation of the major chicken vitellogenin geneCell, 1983
- Methylation of the chicken vilellogenin gene: influence of estradiol administrationNucleic Acids Research, 1983
- High affinity binding of anti-oestrogen to the chick liver nuclear oestrogen receptorBiochemical Journal, 1982
- Isolation and characterization of a cDNA clone specific for avian vitellogenin IINucleic Acids Research, 1982
- Differential ontogeny of estrogen responsiveness in the chick embryo liverCanadian Journal of Biochemistry, 1981
- Oestrogen receptor levels and vitellogenin synthesis during development of Xenopus laevisNature, 1981
- Synthesis of apoprotein B of very low density lipoprotein in embryonic-chick liver. Development of responsiveness of oestrogenBiochemical Journal, 1980
- Coordinate regulation of two estrogen-dependent genes in avian liver.Proceedings of the National Academy of Sciences, 1980
- Ontogeny of the vitellogenic response to oestradiol and of the soluble nuclear oestrogen receptor in embryonic-chick liverBiochemical Journal, 1978
- Albumin synthesis and secretion by isolated morphologically characterized avian hepatic parenchymal cellsLife Sciences, 1978