Enhanced In Vitro Inhibition of HIV-1 Replication by 3′-Fluoro-3′-deoxythymidine Compared to Several Other Nucleoside Analogs
- 1 January 1988
- journal article
- research article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 4 (6) , 457-466
- https://doi.org/10.1089/aid.1988.4.457
Abstract
Nucleoside analogs were synthesized and tested for anti-HIV-1 activity in two in vitro test systems using MT-4 cells and peripheral blood lymphocytes. Cytotoxicity was assessed in both assays and additionally in several human lymphoblastoid cell lines. One analog, 3′fluoro-3′-deoxythymidine, exhibited higher antiviral potency and slightly higher cytotoxicity than 3′-azido-3′-deoxythymidine. Analogs showing lower cytotoxicity than 3′-azido-3′deoxythymidine demonstrated reduced antiviral activity. 3′-Fluoro-3′-deoxythymidine may become an alternative chemotherapeutic agent because of its high antiretro viral potency. Its toxicity, however, deserves further investigation.This publication has 35 references indexed in Scilit:
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