The role of Mg2+ and specific amino acid residues in the catalytic reaction of the major human abasic endonuclease: new insights from EDTA-resistant incision of acyclic abasic site analogs and site-directed mutagenesis
- 9 July 1999
- journal article
- Published by Elsevier in Journal of Molecular Biology
- Vol. 290 (2) , 447-457
- https://doi.org/10.1006/jmbi.1999.2888
Abstract
No abstract availableKeywords
This publication has 28 references indexed in Scilit:
- Conversion of bovine pancreatic DNase I to a repair endonuclease with a high selectivity for abasic sitesThe EMBO Journal, 1998
- Elements in abasic site recognition by the major human and Escherichia coli apurinic/apyrimidinic endonucleasesNucleic Acids Research, 1998
- Mechanism of Phosphatidylinositol-Specific Phospholipase C: A Unified View of the Mechanism of Catalysis,Biochemistry, 1998
- Evidence for a Common Active Site for Cleavage of an AP Site and the Benzene-Derived Exocyclic Adduct, 3,N4-Benzetheno-dC, in the Major Human AP EndonucleaseBiochemistry, 1997
- The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sitesThe EMBO Journal, 1997
- Regulation of eukaryotic abasic endonucleases and their role in genetic stability.Environmental Health Perspectives, 1997
- Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis.Proceedings of the National Academy of Sciences, 1996
- Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1Nature Structural & Molecular Biology, 1995
- REPAIR OF OXIDATIVE DAMAGE TO DNA: Enzymology and BiologyAnnual Review of Biochemistry, 1994
- Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes.Proceedings of the National Academy of Sciences, 1991