STUDIES OF PATHWAYS OF GLUCOSE METABOLISM OF ENDOCRINE TISSUES

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Abstract
Pathways of glucose oxidation using glucose-1-C14 and glucose-6-C14 have been studied in vitro in adrenal, ovary, testis, pituitary and parathyroid slices. The results indicate the existence of an active hexose monophosphate pathway in all endocrine glands studied. Although in similar experiments TSH in vitro was capable of stimulating glucose oxidation in thyroid (1), no effects of FSH, LH, chorionic gonadotrophin or anterior pituitary powder were observed in ovary or testis. Neither ACTH nor 3''5[image] cyclic adenosine monophosphate inhibited glucose oxidation in slices of adrenal cortex. Possible causes for this absence of inhibition are discussed in light of the recent work by Haynes on the mechanism of action of ACTH (6). The hexose monophosphate pathway for glucose metabolism in endocrine tissue is a source of TPNH, and this cofactor may be of importance in the regulation of hormone production.