Zinc (0)-Mediated Formation of Carbon-Carbon Bond from γ-Bromo Crotonate
- 1 January 1982
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 12 (14) , 1147-1154
- https://doi.org/10.1080/00397918208065982
Abstract
The coupling reaction of allylic halides with diffferent organometallic reagents has been widely utilized for synthetic purpose.1 Unfortunately, with the exception of primary halides which give mostly α attack and of hindered substrates which prefer γ attack, the lack of regioselectivity is a great handicap for the generalization of the method.Keywords
This publication has 2 references indexed in Scilit:
- Stereoselective synthesis of 1,4-dienes and mono-olefins by methylcopper-induced cross-coupling of dialkenylchloroboranes with organic halidesJournal of the Chemical Society, Chemical Communications, 1976
- Chemistry of enolates from zinc reduction of .alpha.-bromo ketones. New method of substitution .alpha. to carbonyl groupsJournal of the American Chemical Society, 1967