Experiences in One Hundred Thirty-Seven Patients Treated with Oral Griseofulvin

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Abstract
Shortly after the original publication of Gentles1on the effectiveness of griseofulvin in Trichophyton infections of laboratory animals, numerous investigators have reported on striking clinical results obtained with the oral administration of griseofulvin in treatment of superficial dermatomycoses in man. Williams et al.,2Riehl,3Blank and Roth,4and Pardo-Castello5were among the first attempting such clinical studies. A main purpose of this paper is to evalu ate the recurrences noted in patients either after completion of a course of oral therapy with griseofulvin or in evidenceduring the course of treatment. The management of these cases will be discussed. Several patients, moreover, were found to have persistently positive mycological laboratory findings despite apparent clinical cure. This situation we have designated as the "healthy carrier state." Method We wish to call attention to the fact that our studies commenced in the winter months and extended into

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