Diet and oral antidiabetic drugs and plasma sugar and insulin levels in patients with maturity-onset diabetes mellitus.
- 28 February 1976
- Vol. 1 (6008) , 498-500
- https://doi.org/10.1136/bmj.1.6008.498
Abstract
A longitudal study was carried out to separate the effects of treatment with diet from those of treatment with glibenclamide and phenformin on the oral glucose tolerance test (OGTT) plasma sugar and insulin levels in 118 patients with maturity-onset diabetes mellitus. Both drugs improved glucose tolerance and random blood sugar levels more than diet alone. The improved glucose tolerance with both drugs was due to a combination of a reduced fasting plasma sugar level and an improved tolerance to the glucose load. Treatment with glibenclamide increased insulin secretion but phenformin had no significant effect. Mean body weight fell slightly during phenformin administration, whereas a small but insignificant rise in patients receiving glibenclamide.Keywords
This publication has 8 references indexed in Scilit:
- INFLUENCE OF TREATMENT WITH DIET ALONE ON ORAL GLUCOSE-TOLERANCE TEST AND PLASMA SUGAR AND INSULIN LEVELS IN PATIENTS WITH MATURITY-ONSET DIABETES MELLITUSThe Lancet, 1975
- A SENSITIVE, PRECISE RADIOIMMUNOASSAY OF SERUM INSULIN RELYING ON CHARCOAL SEPARATION OF BOUND AND FREE HORMONE MOIETIESActa Endocrinologica, 1972
- Glucose and Insulin Secretory Response Patterns Following Diet and Tolazamide Therapy in DiabetesBMJ, 1970
- Study of the Relationship Between Glucose and Insulin Responses to an Oral Glucose Load in ManDiabetes, 1968
- Effect of Chlorpropamide on Serum Glucose and Immunoreactive Insulin Concentrations in Patients with Maturity-onset Diabetes MellitusDiabetes, 1967
- Treatment of the obese diabeticMetabolism, 1967
- The effects of long-term acetohexamide treatment on pancreatic islet cell function in maturity-onset diabetesMetabolism, 1966
- SOME EFFECTS OF ORAL CONTRACEPTIVES ON CARBOHYDRATE METABOLISMThe Lancet, 1966