Frequent isolation of intertypic poliovirus recombinants with serotype 2 specificity from vaccine‐associated polio cases
- 1 December 1991
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 35 (4) , 290-296
- https://doi.org/10.1002/jmv.1890350415
Abstract
Five representatives from a collection of 21 Sabin type 2-like poliovirus strains isolated from paralytic poliomyelitis cases in two regions of the USSR have been subjected t o limited nucleotide sequencing. All proved to be intertypic recombinants having the genes encoding capsid proteins of Sabin 2 origin and a 3'-end portion of the genome derived from either type 1 (3 isolates) or type 3 (2 isolates) Sabin strains. The crossover points in all the 5 genomes have been mapped to different loci of the P3 region. At least 6 additional isolates from the same collection (and 2 isolates from healthy contacts), appeared to have a type 2/type 1 recombinant genome, as judged by oligonucleotide mapping. The biological significance of frequent occurrence of recombinants among field isolates of vaccine-related strains is discussed.Keywords
This publication has 27 references indexed in Scilit:
- Intertypic genomic rearrangements of poliovirus strains in vaccineesVirology, 1988
- The Effect of Sequences in the 5' Non-coding Region on the Replication of Polioviruses in the Human GutJournal of General Virology, 1988
- Antigenic and Molecular Evolution of the Vaccine Strain of Type 3 Poliovirus during the Period of Excretion by a Primary VaccineeJournal of General Virology, 1986
- Oral Poliovirus Vaccine: History of Its Development and Use and Current Challenge to Eliminate Poliomyelitis from the WorldThe Journal of Infectious Diseases, 1985
- Complete nucleotide sequences of all three poliovirus serotype genomesJournal of Molecular Biology, 1984
- Characterization of Strains of Type 3 Poliovirus by Oligonucleotide MappingJournal of General Virology, 1982
- Multiple Genetic Changes Can Occur in the Oral Poliovaccines upon Replication in HumansJournal of General Virology, 1981
- Vaccine-associated poliomyelitis in a child with sex-linked agammaglobulinemiaThe Journal of Pediatrics, 1977
- Chronic Progressive Poliomyelitis Secondary to Vaccination of an Immunodeficient ChildNew England Journal of Medicine, 1977
- Poliomyelitis in HypogammaglobulinemicsThe Journal of Infectious Diseases, 1973