Selenium Responsive Myositis during Prolonged Home Total Parenteral Nutrition in Cystic Fibrosis

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Abstract
The need for routine supplementation of total parenteral nutrition solutions with selenium (Se) has not been clearly defined. Although clinical selenium deficiency in patients on prolonged total parenteral nutrition has been reported, it is rarely observed in the United States. We report a 19‐year‐old woman with cystic fibrosis who developed muscle pain and weakness after 3 months on total parenteral nutrition which was not supplemented with Se. Coincident with her onset of symptoms, markedly elevated serum creatine kinase values were observed compared to baseline levels. Subsequent evaluations revealed undetectable ((Journal of Parenteral and Enteral Nutrition 9:58–60, 1985)