Determination of microscopic dissociation constants of 3-hydroxy-α-(methylamino)methyl-benzenemethanol by a spectral deconvolution method
- 1 July 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 41 (7) , 485-488
- https://doi.org/10.1111/j.2042-7158.1989.tb06506.x
Abstract
Microscopic dissociation constants of 3-hydroxy-α-(methylamino)methyl-benzenemethanol have been calculated from the titration spectrophotomeric data (c = 3·8 × 10−4 M. Ionic strength = 0·16; buffer system: H3BO3/KOH) by application of a spectral deconvolution method. The results found (pKa = 9·48; pKb = 9·71; pKc = 10·12 and pKd = 9·88) are in good concordance with those obtained from the conventional regression linear method (pKa = 9·45; pKb = 9·77; pKc = 10·14 and pKd = 9·81).This publication has 3 references indexed in Scilit:
- Band-shape analysis and resolution of electronic spectra of pyridoxal phosphate and other 3-hydroxypyridine-4-aldehydesBiochimica et Biophysica Acta (BBA) - General Subjects, 1976
- Graphical methods for determining the number of species in solution from spectrophotometric dataInorganic Chemistry, 1970
- Acid Dissociation Constants of PhenylalkanolaminesJournal of Pharmaceutical Sciences, 1962