EXPERIMENTAL AND CLINICAL ACTIVITY OF MITOMYCIN-C AND CIS-DIAMMINEDICHLOROPLATINUM IN MALIGNANT MESOTHELIOMA

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 44  (4) , 1688-1692
Abstract
Little information is available regarding the effectiveness of chemotherapeutic agents in malignant mesothelioma. Human malignant mesothelioma specimens form 2 patients were successfully transplanted and maintained in homozygous nude mice. Screening of chemotherapeutic agents revealed that cisplatin was the most active single agent in 1 line, and mitomycin C in the other. The combination of mitomycin C and cisplatin, however, was the most effective regimen for both lines of xenografted human mesothelioma. Based on these results in nude mice, a clinical trial of mitomycin C and cisplatin was undertaken. Four of 12 patients showed objective response (1 complete and 3 partial). These clinical results support the usefulness of the nude mouse model for malignant mesothelioma.

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