The Lack of Effect of Intramuscular Emepronium Bromide for Urinary Incontinence

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Abstract
Six elderly volunteers (4 men and 2 women), suffering from urinary incontinence due to small capacity, hyper-reflexic bladders, were assessed cystometrically 1/2, 1 and 4 h after an i.m. injection of emepronium bromide (Cetiprin). The dose given was sufficient to raise serum levels of emepronium to .apprx. 10 times those that could be reached with an oral dose. Apparently, there was no significant difference in the state of the bladder at any time. Emepronium bromide may be ineffective in increasing bladder capacity in subjects with small, hyper-reflexic bladders. It may have no value in the management of urinary incontinence in elderly patients with this condition.

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