Paresis and hyperexcitability in adynamia episodica hereditaria

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Abstract
The disease presents an increase in serum K accompanying attacks of muscular weakness when provoked by administration of KC1 or by rest after physical exertion. The transient paresis is characterized by a reduction in the number of muscle fibers which can be activated, the electromyogram showing a single oscillation pattern at maximum effort and a 16-32% reduction in the mean duration of action potentials. Signs of hyperexcitability also appear during the attack. The findings are interpreted as a partial depolarization of the excitable membrane, causing a block of some muscle fibers and a hyperexcitability in others. There are indications that the changes appear mainly at the neuromuscular junction.