PHASE-II STUDY OF HIGH-DOSE METHOTREXATE IN THE TREATMENT OF PATIENTS WITH NON-SMALL CELL-CARCINOMA OF THE LUNG - AN EASTERN COOPERATIVE ONCOLOGY GROUP-STUDY

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 64  (10-1) , 1017-1021
Abstract
Patients (28) with inoperable non-small cell carcinoma of the lung were treated with high-dose methotrexate with citrovorum factor rescue. One patient (4%) responded with a partial regression of the tumor. Three patients had the following severe or life-threatening complications: acute renal failure, acute shortness of breath and bone marrow suppression respectively. There is 98% confidence that the true response rate for this therapy is < 20%. High-dose methotrexate with citrovorum factor rescue in the schedule utilized apparently is not effective in the treatment of patients with non-small cell carcinoma of the lung.

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