ABSENCE OF A PRENIDATORY EFFECT OF LUTEINIZING-HORMONE RELEASING HORMONE (LHRH) IN HAMSTERS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 22  (1) , 40-43
Abstract
Luteinizing hormone releasing hormone at high doses will terminate gestation in rats during early and midpregnancy (ED50 .simeq. 100 .mu.g/day) and rabbits during early pregnancy. Early pregnancy in hamsters, in contradistinction, seems refractory to this effect. Administration of LHRH up to massive doses (10 mg/day) over the first 3 or 7 days of pregnancy failed to affect the pregnancies in meaningful fashion. A single injection (100 mg) on day 5 had no effect on pregnancy; this system was employed for the assay of prostaglandins [PG] because hamsters are remarkably sensitive to PG (PGF2.alpha., ED50 .simeq. 17 .mu.g; PGE2, ED50 .simeq. 210 .mu.g). The absence of response of hamster to LRHR cannot be interpreted at present.

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