An explanation for the increasing incidence of testis cancer: decreasing age at first full-term pregnancy.
Open Access
- 4 June 1997
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 89 (11) , 818-820
- https://doi.org/10.1093/jnci/89.11.818
Abstract
For unknown reasons, the incidence of cancer of the testis has increased substantially among white male populations of several European countries, the United States, Australia, and New Zealand (1). In Japan, the rates of testicular cancer have increased recently as well (2). An increase in the rate in white populations was first noted among men born after 1920, but this increase was not consistently sustained for men born between 1930 and 1945 (1). However, for men born in the 1950s onward, the increase in incidence has been uninterrupted. Explanations for this secular increase have been elusive. To some investigators, reports of a concomitant decrease in sperm counts in young men have suggested that an environmental exposure (e.g., pesticides and plant phytoestrogens) might be responsible (3).Keywords
This publication has 6 references indexed in Scilit:
- Increase in Testicular Cancer Incidence in Six European Countries: a Birth Cohort PhenomenonJNCI Journal of the National Cancer Institute, 1996
- Decreased fertility in Britain compared with FinlandThe Lancet, 1996
- Hyperemesis gravidarum in relation to estradiol levels, pregnancy outcome, and other maternal factors: A seroepidemiologic studyAmerican Journal of Obstetrics and Gynecology, 1987
- Maternal and Gestational Factors Affecting the Risk of Cryptorchidism and Inguinal HerniaInternational Journal of Epidemiology, 1984
- Risk factors for cancer of the testis in young menInternational Journal of Cancer, 1979
- Cryptorchidism, Hernia, and Cancer of the Testis 2 3JNCI Journal of the National Cancer Institute, 1976