5-Fluorouracil derivatives. XVII. Synthesis and antitumor activity of 5'-O-acyl-5-fluorouridines.
- 1 January 1989
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 37 (12) , 3405-3408
- https://doi.org/10.1248/cpb.37.3405
Abstract
With the aim of diminishing the toxicity of 5-fluorouridine (1) and obtaining biologically active derivatives of 1, various kinds of 5''-O-acyl-5-fluorouridines 2 were synthesized. The antitumor activity of the compounds against L-1210 leukemia in mice was examined. The 5''-O-heptanoyl derivative 2 h showed the highest antitumor activity.This publication has 1 reference indexed in Scilit:
- Nucleosides. 114. 5'-O-Glucuronides of 5-fluorouridine and 5-fluorocytidine. Masked precursors of anticancer nucleosidesJournal of Medicinal Chemistry, 1981