POTENTIATION OF PENTOBARBITAL SLEEPING TIME BY CHLOROQUINE IN THE RAT

  • 1 January 1980
    • journal article
    • research article
    • Vol. 243  (2) , 192-196
Abstract
The effects of chronic administration of chloroquine on pentobarbitone sleeping time was studied in albino rats. Administration of chloroquine (20 mg/kg s.c.) for 21 days significantly increased pentobarbitone sleeping time by 16-105% within that period. A combination of chloroquine (20 mg/kg s.c.) and pentobarbitone (20 mg/kg s.c.) not only antagonized that usual decreased pentobarbitone sleeping time when pentobarbitone is given alone but increased it by 34-56% within 7-14 days. In chloroquine chronic pretreated rats injection of sub-anesthetic doses of pentabarbitone (20 mg/kg i.p.) produced anesthesia for 42.15 .+-. 4.6 min while untreated rats became only ataxic. These effects of chloroquine may be due to a decrease in the metabolism of pentobarbitone in the liver.

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