Potassium-sparing Agents during Diuretic Therapy in Hypertension
- 26 June 1971
- Vol. 2 (5764) , 739-741
- https://doi.org/10.1136/bmj.2.5764.739
Abstract
Three pharmacological agents in use as “potassium-sparing” drugs have been tested by serial measurements of total exchangeable potassium (KE) during 4 to 12 weeks of oral diuretic therapy in hypertensive subjects. Triamterene seemed ineffective in the dosage used (50 mg twice daily). Spironolactone (25 mg twice daily) reduced K loss to a considerable extent, while Slow-K (32 mEq daily) completely reversed previous KE deficits. Plasma K levels were a poor indication of degree of KE restoration.Keywords
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