PHARMACOLOGY OF ANTITUMOR AGENTS FROM HIGHER-PLANTS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 60  (8) , 1127-1139
Abstract
Some pharmacologic properties of nine antitumor agents from higher plants are described. The agents are vincristine, vinblastine the epiodophyllotoxin derivatives VM-26 and VP-16-213, maytansine, bruceantin, thalicarpine, camptothecin, and lapachol. When sufficient information is available, the agents are discussed with regard to their antitumor activity, mechanism of action, pharmacologic disposition, structure-activity relationships, and toxicity.

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