HLA‐DRB1* GENE SEQUENCES IN HLA‐DR4 POSITIVE AND NEGATIVE PATIENTS WITH RHEUMATOID ARTHRITIS
- 2 April 1993
- journal article
- Published by Wiley in International Journal of Immunogenetics
- Vol. 20 (2) , 83-89
- https://doi.org/10.1111/j.1744-313x.1993.tb00096.x
Abstract
The second exon of the DRB1 gene encoding for the first domain of the HLA-DR β-chain was sequenced in 16 patients (10 DR4/DR1 positive, 6 DR4/DR1 negative) with seropositive rheumatoid arthritis (RA). We could confirm the strong association of susceptibility to RA with functionally equivalent conformations on otherwise distinct MHC molecules. At least one HLA-DR allele in all of the analysed DR4 or DR1 positive patients showed such an epitope with a minimal variability limited to residue 71. However, in HLA-DR4 and -DR1 negative patients such a similar epitope could not be detected.Keywords
This publication has 38 references indexed in Scilit:
- Nomenclature for factors of the HLA system, 1989Human Immunology, 1990
- Further DNA sequence microheterogeneity of the HLA-DR4/Dw13 haplotype group: Importance of amino acid position 86 of the DRβ1 chain for T-cell recognitionHuman Immunology, 1990
- Involvement of class II β-chain amino acid residues 85 and 86 in T-cell allorecognitionHuman Immunology, 1990
- Shared molecular markers of genetic predisposition to seropositive rheumatoid arthritisHuman Immunology, 1990
- A novel T-cell-defined HLA-DR polymorphism not predicted from the linear amino acid sequenceHuman Immunology, 1989
- DNA sequence analysis of the HLA-DRw12 alleleHuman Immunology, 1989
- HLA-Dw14 and HLA-DR3 haplotypes share a functional determinant recognized by a human alloreactive T-cell cloneHuman Immunology, 1988
- The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisArthritis & Rheumatism, 1988
- The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritisArthritis & Rheumatism, 1987
- Dw subtypes of DR4 in rheumatoid arthritis: Evidence for a preferential association with Dw4Human Immunology, 1986