Readily Prepared Chiral P,N Ligands and Their Applications in Cu-Catalyzed Enantioselective Conjugate Additions

Abstract
A new type of phosphite−pyridine (P,N) ligand derived from (S)-NOBIN and (S)-BINOL was employed in Cu(I)-catalyzed conjugate addition of diethylzinc to chalcones. The new P,N ligands were highly efficient in the copper-catalyzed enantioselective 1,4-conjugate additions of diethylzinc to acyclic enones, and up to 97% ee was achieved.