Readily Prepared Chiral P,N Ligands and Their Applications in Cu-Catalyzed Enantioselective Conjugate Additions
- 1 May 2003
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 68 (11) , 4542-4545
- https://doi.org/10.1021/jo0340758
Abstract
A new type of phosphite−pyridine (P,N) ligand derived from (S)-NOBIN and (S)-BINOL was employed in Cu(I)-catalyzed conjugate addition of diethylzinc to chalcones. The new P,N ligands were highly efficient in the copper-catalyzed enantioselective 1,4-conjugate additions of diethylzinc to acyclic enones, and up to 97% ee was achieved.Keywords
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