Rhabdomyosarcoma of the head and neck in children

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Abstract
Children (17) with rhabdomyosarcoma arising in the head and neck are presented. With a median follow-up of 2 yr 3 mo., 11 patients are currently living, 7 patients are alive free of disease, and local control was achieved in 11 patients. Of 13 group III patients managed with irradiation and chemotherapy following biopsy, 7 patients are alive, with 4 patients free of disease, and local control achieved in 8 patients. In a subgroup of 9 group III patients with tumor involving multiple head and neck sites, 4 patients are alive, with 2 patients free of disease, and local control achieved in 6 patients. In 4 groups I-II patients, local control was achieved in 3, and all patients are currently living. Long-term complications include facial bone hypoplasia in 3 patients and cataracts in 3 patients. Primary irradiation and chemotherapy can locally control rhabdomyosarcoma of the head and neck, while avoiding the functional and cosmetic sequelae associated with surgical ablation.

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