Comparative Studies of the Growth-Stimulating Properties of Phenothiazine Analogs in the Rat

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Abstract
Growth-stimulating properties and efficiency of food utilization of phenothiazine analogs were studied in the rat. Within a narrow dose range it was observed that certain phenothiazine analogs significantly stimulated the growth of young adult male rats. No significant growth stimulation was observed when these compounds were administered to young adult female rats, immature male or female rats or to young adult castrate male rats. Food consumption data collected during the eighth week of testing indicated that chronic administration of the phenothiazines stimulated appetite and increased the efficiency of food utilization in young adult male rats. Structure-activity relationships to growth-stimulating properties of the phenothiazines studied were discussed.