Intron exclusion and the mystery of intron loss
- 7 November 2006
- journal article
- Published by Wiley in FEBS Letters
- Vol. 580 (27) , 6361-6365
- https://doi.org/10.1016/j.febslet.2006.10.048
Abstract
Mechanisms for loss and gain of introns are elusive. Reported here is a new pattern of intron loss which features a random loss of a single intron in a multiple-intron gene with its neighboring introns remained, which process is defined as intron exclusion. Intron exclusion is reminiscent of removal of a limited stretch of non-homologous sequence in a homologous recombination (HR) triggered by a double strand break (DSB), and therefore lends further evidence for a theory of intron loss through HR between a cDNA and its genomic intron-containing locus. Thus, a model for intron loss is formulated.Keywords
This publication has 30 references indexed in Scilit:
- Complete, precise, and innocuous loss of multiple introns in the currently intronless, active cathepsin L-like genes, and inference from this eventMolecular Phylogenetics and Evolution, 2006
- Reverse transcriptase and integrase of the Saccharomyces cerevisiae Ty1 elementCytogenetic and Genome Research, 2005
- DSB repair: the yeast paradigmPublished by Elsevier ,2004
- The evolution of spliceosomal intronsCurrent Opinion in Genetics & Development, 2002
- Origin of introns–early or late?Nature, 1994
- Five identical intron positions in ancient duplicated genes of eubacterial originNature, 1994
- A role for reverse transcripts in gene conversionNature, 1993
- Pseudogenes in yeast?Cell, 1987
- NONVIRAL RETROPOSONS: GENES, PSEUDOGENES, AND TRANSPOSABLE ELEMENTS GENERATED BY THE REVERSE FLOW OF GENETIC INFORMATIONAnnual Review of Biochemistry, 1986
- How Mammalian RNA Returns to Its GenomeScience, 1983