A Malaria Vaccine Based on a Sporozoite Antigen

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Abstract
Malaria was eliminated from many temperate-zone countries in the 1940s, and in the next decade its prevalence was drastically reduced in several tropical countries. However, in recent years, this infection has undergone a resurgence in most tropical regions. Currently, malaria occurs in over 90 countries, and according to World Health Organization estimates, it causes up to 500 million clinical cases and 2.7 million deaths per year. Plasmodium falciparum is the most prevalent of the four malaria parasites of humans and causes most of the severe and lethal infections affecting young children and nonimmune adults. The P. vivax species also causes . . .

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