Structural variability of the neutral carbohydrate moiety of cow colostrum κ‐casein as a function of time after parturition

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Abstract
New neutral oligosaccharides from cow colostrum κ-casein were identified and characterized by 500-MHz 1H-NMR spectroscopy. Their structures are Galβ(1→3)GalNAc-ol, Galβ(1→3)[GlcNAcβ(1→6)]GalNAc-ol, Galβ(1→3)[Galβ(1→4)GlcNAcβ(1→6)]GalNAc-ol, Galβ(1→3){Fucα(1→3)[Galβ(1→4)]GlcNAcβ(1→6)}Gal-NAc-ol. The tetrasaccharide and the cow colostrum κ-caseinoglycopeptide which contains this oligosaccharide inhibit the hemagglutination of blood group I human erythrocytes. In cow mature milk only the disaccharide is characterized. The variability of these neutral oligosaccharides in cow κ-casein as a function of time after calving is studied.