Localized prevention of postsurgical adhesion formation and reformation with oxidized regenerated cellulose

Publisher Website
Google Scholar
Abstract
We evaluated oxidized regenerated cellulose (ORC) in experimental rabbit and dog models to assess its potential for reducing or preventing adhesion formation and reformation. Evaluation was performed in the following anatomical sites: (1) uterine horn trauma; (2) small bowel resection and anastomosis; (3) parietal peritoneum excision; and (4) adhesion reformation in the uterine horn. Ten to 14 days after ORC treatment, adhesion formation was macroscopically and microscopically evaluated. Results demonstrate that ORC produced graded reduction in adhesion formation and significantly prevented adhesion reformation.