Correlation of the oxygen cost of breathing and length of weaning from mechanical ventilation
- 1 September 1987
- journal article
- research article
- Published by Wolters Kluwer Health in Critical Care Medicine
- Vol. 15 (9) , 807-812
- https://doi.org/10.1097/00003246-198709000-00001
Abstract
We studied 20 patients (ages 43 to 84 yr), whose forced vital capacity, peak negative inspiratory pressure and alveolar-arterial gradient indicated that they were unlikely to be withdrawn rapidly from mechanical ventilation. Their mean oxygen consumption (Vo2) during controlled ventilation (CV) was 292 ± 21 (SEM) ml/min. During spontaneous ventilation (SV) through endotracheal tube and ventilator circuit, the Vo2 rose significantly (p < .001) to 323 ± 20 ml/min. The oxygen cost of breathing (OCB) (the difference in Vo2 between CV and SV) and the OCB as a fraction of the oxygen consumed during SV (OCB/Vo2 SV) both correlated significantly by linear regression analysis with the total time to wean in days (-11.6 + 0.93 for OCB, r = .79; and −12.6 + 293.1 for OCB/Vo2 SV, r = .84, p < .001 for both). As the OCB was correlated with the total wean time, this variable may be a useful index of the effect of many influences on the weaning process.Keywords
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