ELECTROCARDIOGRAPHIC STUDIES DURING ENDOTRACHEAL INTUBATION. III. EFFECTS DURING GENERAL ANESTHESIA AND INTRAVENOUS DIETHYLAMINOETHANOL

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Abstract
Ecg''s were obtained in 114 anesthetized adult patients who were intubated during anesthesia with various agents and in whom diethylaminoethanol (DEAE), a primary hydrolytic product of procaine, was administered intraven. prior to endotracheal intubation. At the time of intubation 12% of the cases showed ecg. disturbances, which consisted mainly of sinus tachycardia and ventricular extrasystoles. In a previous series without diethylaminoethanol, the incidence was 68%. Topical cocainization of the pharynx and larynx during general anesthesia appeared to increase the cardiac disorders. The incidence and severity of cardiac arrhythmias usually encountered at the time of endotracheal intubation was reduced and alleviated by diethylaminoethanol. Diethylaminoethanol is less toxic than procaine and its effective dose is at least 10 times that of procaine.

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