Effect of ryanodine on cardiac muscle

Publisher Website
Google Scholar
Abstract
Ryanodine (1 x 10–8 m) exerted a negative inotropic effect on toad ventricular muscle. The amplitude of contractions recorded from ryanodine-depressed ventricles were enhanced by raising the rate of stimulation, by increasing the extracellular Ca++ concentration, and by the addition of caffeine. The negative inotropic effect of ryanodine was reversed following perfusion with Tyrode solution containing 4 mm ethylenediaminetetraacetic acid.