Radiocolloid Studies of the Regression of Intrasplenic Lesions

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Abstract
Cases [5] are presented in which intrasplenic defects, noted on 99mTc S colloid imaging, had at least partially regressed on follow-up studies. One, representing splenic trauma, reinforced the concept of the ability of the spleen to heal itself. A 2nd case involved splenic invasion by direct extension of a soft tissue sarcoma. Improvement was noted after the patient was treated with chemotherapy. Three cases were related to splenic manifestations of lymphoma. Of these 3 patients (one each with lymphocytic, histiocytic and mixed diffuse histiocytic lymphoma plus nodular), 2 showed improvement after treatment with chemotherapy alone and the 3rd after combined chemotherapy and external radiation treatment. Return of splenic reticuloendothelial function to previously involved regions within the spleen occurred for all 5 patients. Comments were made as to the apparent rate of return of function.

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