The Effect of Altered Thyroid State on Prolactin Binding to Liver and 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors in Rats

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Abstract
The effects of propylthiouracil (PTU) and pharmacological doses of thyroxine (T4) on growth and prolactin (PRL)-binding activity of DMBA [7,12-dimethyl benz(a) anthracene]-induced mammary tumors were studied. The hypo- or hyperthyrodism induced by these respective treatments did not affect the growth rate of established tumors, PRL binding activity in these tumors or plasma PRL in the tumor-bearing rats. PTU and T4 treatments caused a large reduction of PRL binding activity in the liver.